Epigenetic Regulation of Placental NR3C1 : Mechanism Underlying Prenatal Programming of Infant Neurobehavior by Maternal Smoking?
نویسندگان
چکیده
منابع مشابه
Prenatal predictors of infant self-regulation: the contributions of placental DNA methylation of NR3C1 and neuroendocrine activity
We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still-face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode wa...
متن کاملPrenatal maternal stress programs infant stress regulation.
OBJECTIVE Prenatal exposure to inappropriate levels of glucocorticoids (GCs) and maternal stress are putative mechanisms for the fetal programming of later health outcomes. The current investigation examined the influence of prenatal maternal cortisol and maternal psychosocial stress on infant physiological and behavioral responses to stress. METHODS The study sample comprised 116 women and t...
متن کاملMaternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation.
Prenatal maternal psychological distress increases risk for adverse infant outcomes. However, the biological mechanisms underlying this association remain unclear. Prenatal stress can impact fetal epigenetic regulation that could underlie changes in infant stress responses. It has been suggested that maternal glucocorticoids may mediate this epigenetic effect. We examined this hypothesis by det...
متن کاملAltered placental DNA methylation patterns associated with maternal smoking: current perspectives
The developmental origins of health and disease hypothesis states that adverse early life exposures can have lasting, detrimental effects on lifelong health. Exposure to maternal cigarette smoking during pregnancy is associated with morbidity and mortality in offspring, including increased risks for miscarriage, stillbirth, low birth weight, preterm birth, asthma, obesity, altered neurobehavior...
متن کاملPrenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses.
BACKGROUND In animal models, variations in early maternal care are associated with differences in hypothalamic-pituitary-adrenal(HPA) stress response in the offspring, mediated via changes in the epigenetic regulation of glucocorticoid receptor (GR) gene (Nr3c1) expression. OBJECTIVE To study this in humans, relationships between prenatal exposure to maternal mood and the methylation status o...
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ژورنال
عنوان ژورنال: Child Development
سال: 2016
ISSN: 0009-3920
DOI: 10.1111/cdev.12482